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Soluble Hyperthermic Particles Destroy Cancer Cells, Fibroids and Cellulite

This novel soluble hyperthermic particles technology offers a soluble compound capable of heating and ablating unwanted tissues for a wide range of applications while producing minimal biocompatibility issues.

Technology Overview

Reference #: 12-57

Researchers at Wake Forest University and Wake Forest School of Medicine have developed novel soluble hyperthermic particles that are capable of generating hyperthermia to destroy cancer cells. Upon stimulation with a laser, the particles produce heat, which has been shown to reduce total colorectal cancer cell viability to 5-10%. This technology has potential for use in the treatment of cancer or other diseases involving hyperplastic tissue.

Hyperthermia-induced ablation is emerging as a less invasive and more efficient alternative to surgical means of removing solid tumors or hyperplastic tissues. Most hyperthermic technologies available rely on metal-based compounds, which are less thermally stable and do not catabolize in the body.

  • The soluble hyperthermic particles have been validated in vitro using HCT116 and RKO colorectal cancer cells.
  •  In vivo animal testing is currently ongoing.
  • Nicole Levi, PhD, Department of Plastic Surgery
  • Christopher MacNeill, PhD, Department of Plastic Surgery
  • David L. Carroll, PhD, Department of Physics

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John Druga
John Druga, MS, MBA
Licensing Director, Technology Commercialization