A Novel Antibody as an Identifier of Erythroid Precursors in Bone Marrow Biopsy Specimens

Accurately identifying early erythroid precursors is crucial in acute erythroid leukemia (M6) diagnosis.

Ferritin H is an excellent identifierof erythroid precursors in bone marrow specimens. Compared to traditional markers that express at relatively low levels in early erythroid precursors while high levels in mature erythrocytes, Ferritin has the highest expression only in early erythroid precursors, and its expression is negative in mature erythrocytes and other hematopoietic lineages. The Ferritin H antibody is a more reliable diagnostic tool used in immunohistochemistry to identify acute erythroid leukemia (M6), a disease diagnosed by the presence of early erythroid precursors.

Invention Summary

Researchers at Wake Forest School of Medicine have designed a monoclonal antibody to a specific epitope of Ferritin H. The Ferritin H antibody can be applied in immunohistochemistry to stain Ferritin in early erythroid precursors. It is used as a marker of early erythroid precursors to diagnose acute erythroid leukemia (M6) and other diseases associated with erythroid dysplasia.

Benefits

  • Ferritin H is expressed specifically in erythroid precursors, making it is a more reliable marker of early erythroid precursors to diagnose M6.
  • The Ferritin H antibody is novel, easy to use and has no cross-activity.
  • The Ferritin H antibody can also be used to stain macrophages for research and diagnostic purposes.

Stage of Development

  • Validated
  • Preliminary study using bone marrows with different types of leukemia has been performed. Ferritin H is expressed specifically in erythroid precursors, and the antibody can accurately identify acute erythroid leukemia (M6).

Inventors

  • Michael Beaty, MD
  • Suzy Torti, PhD (University of Connecticut)
  • Frank M. Torti, MD (University of Connecticut)
  • Wei Wang, PhD, MD

Licensing Contact

Deepika Poranki, PhD
dporanki@wakehealth.edu

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