A novel proprietary photosensitizer that uses highly selective photodepletion to prevent graft-versus-host disease in stem cell transplant patients with cancers of the blood. The photosensitizer selectively eliminates the donor T-cells that cause graft-versus-host disease, which may lead to longer survival for stem cell transplant recipients and remove the need for potentially harmful prophylactic immune-suppression.
Patients with cancers of the blood may undergo transplantation of donated stem cells to generate new, normally-functioning bone marrow. In addition to protecting from infection, the donor T-lymphocytes fight cancer cells that might have remained in the body, known as the graft-versus-leukemia effect. However, highly-activated donor T-lymphocyte cells can also cause graft-versus-host disease, where donor cells recognize the patient’s cells as foreign and cause tissue damage. This condition occurs in 60 to 80% of patients undergoing bone marrow transplants. Less than 30% of patients who develop severe acute graft-versus-host disease survive long-term
Current treatment consists of high-dose steroids and other immunosuppressive agents that can lead to health complications such as cytomegalovirus reactivation, infection, and chronic disease which can result in early mortality.
Researchers at Wake Forest Baptist Medical Center have developed a highly selective photodepletion for activated T-cells that uses a novel proprietary photosensitizer called 2-Se-Cl. Such selective photodepletion eliminates T-lymphocytes that cause harmful graft-versus-host disease, keeping healthy lymphocytes that can mediate anti-leukemia, antiviral and antifungal immune responses. This may lead to improved safety and efficacy of stem cell transplants and ultimately improves survival compared to conventional approaches.
- Ex-vivo application of the novel photosensitizer prevented lethal graft-versus-host disease and improved survival after stem cell transplantation in an animal model of the disease
- Photosensitizer is highly selective and maintains antiviral and antileukemic immune responses after photodepletion
- Selective photodepletion of activated T Lymphocytes leads to the reconstitution of antipathogen and antitumor immunity that eliminates infection and cancer and improves survival
- Photosensitizer may make unrelated and HLA-mismatched transplants a safer curative option for more patients
- Prevention of graft-versus-host disease will result in significant financial savings due to the high cost of treating the disease
- Zachariah McIver, MD, Department of Hematology & Oncology
- Michael Detty, PhD, Department of Chemistry, SUNY Buffalo
Leukemia, lymphoma, myelodysplastic syndromes
Stage of Development
Preclinical proof of concept trials are completed, and the technology is on track for preIND product development.
Angiotensin-(1-7), TCAng05, MAS receptor, agonist, breast cancer, prostate cancer, sarcoma, non-toxic chemotherapeutic
McIver, ZA et al. Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease. J. Immunol. 2016; 197(5): 1631-41.
Peter Golikov, MS, MBA, CLP
Licensing Director, Center for Technology Innovation & Commercialization
Ref #: WFU 14-85